Sökning: "Tumour immunology"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden Tumour immunology.

  1. 1. Experimental radioimmunotherapy and effector mechanisms

    Detta är en avhandling från Umeå : Klinisk mikrobiologi

    Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; NATURAL SCIENCES Biology Cell and molecular biology Immunology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi;

    Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

  2. 2. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology Tumour immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 3. Apoptosis induced by a human milk protein complex. Cellular and structural studies in tumour cells and bacteria

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Anders Håkansson; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; nuclear uptake; caspases; mitochondria; S. pneumoniae; alpha-lactalbumin; milk; breast-feeding; Apoptosis; tumour cells; transplantation; Immunologi; serologi;

    Sammanfattning : Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. LÄS MER

  4. 4. Haematopoietic Serine Proteases A Cleavage Specificity Analysis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Michael Thorpe; Lars Hellman; Urban Gullberg; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

    Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER

  5. 5. Studies of Mesenchymal Progenitor Cells and Tumour Growth, Integrins and Matrix Metalloproteinases

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Lars Bryngelsson Ohlsson; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Tumour inhibition; cancer; onkologi; cancerology; Cytologi; oncology; Cytology; Biologi; Biology; Medicin människa och djur ; Medicine human and vertebrates ; Integrin matrix metalloproteinase interaction; Immunologi; serologi; transplantation; Proteins; enzymology; Proteiner; enzymologi; serology; Mesenchumal progenitor cells;

    Sammanfattning : In this thesis we characterize the effect of mesenchymal progenitor cells (MPCs) on tumour growth, and show that MPCs can have inhibitory effects on tumour development. We developed a method to subcutaneously transplant tumour cells, cultured in vitro in a pre-formed gelatin matrix, that made it possible to study the early phases of tumour development. LÄS MER