Sökning: "TLRs"

Visar resultat 1 - 5 av 44 avhandlingar innehållade ordet TLRs.

  1. 1. Studies of the pathogenesis of Enterohemorrhagic Escherichia coli infections: pathogen virulence factors and host response

    Detta är en avhandling från Department of Pediatrics, Lund University

    Författare :Carla Calderon Toledo; Lunds universitet.; Lund University.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; host-pathogen; MyD88; TLRs; LEE; Shiga toxin; HUS; EHEC; EPEC; immune response; virulence factors;

    Sammanfattning : Enterohemorrhagic Escherichia coli (EHEC) is a highly virulent pathogen that can cause diarrhea and a life-threatening disease known as hemolytic uremic syndrome. EHEC possess an array of virulence factors that can exert severe consequences in the host. Shiga toxin constitutes a key virulence factor. LÄS MER

  2. 2. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Mangsbo; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology Tumour immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 3. Toll-like receptors (TLRs) and inflammatory bone modeling

    Detta är en avhandling från Umeå : Umeå University

    Författare :Ali Kassem; Umeå universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toll-like receptor; osteoclast; osteoblast; bone resorption; bone formation; P. gingivalis; S. aureus; flagellin.;

    Sammanfattning : Patients with inflammatory or infectious conditions such as periodontitis, peri-implantitis, osteomyelitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis display varying severity of destruction in the adjacent bone tissue. Bone loss in inflammatory diseases is considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. LÄS MER

  4. 4. Therapeutic dendritic cell vaccination against human papillomavirus

    Detta är en avhandling från Umeå : Umeå University

    Författare :Merja Nurkkala Karlsson; Göteborgs universitet.; Gothenburg University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human papillomavirus; therapeutic dendritic cell vaccination; cholera toxin; T cells; TLRs and CpG;

    Sammanfattning : Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually. The two currently available HPV vaccines can only be used prophylactically, so they are of no use to the 291 million women who are already infected and at risk of developing cancer. LÄS MER

  5. 5. Inflammation in the immature brain: The role of Toll like receptors

    Detta är en avhandling från Umeå : Umeå University

    Författare :Linnea Stridh; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia; immature brain; inflammation; innate immunity; Toll-like receptors;

    Sammanfattning : Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after infectious and endogenous, non-infectious, stimuli. LÄS MER