Sökning: "cleavage specificity"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden cleavage specificity.

  1. 1. Haematopoietic Serine Proteases A Cleavage Specificity Analysis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Michael Thorpe; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

    Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER

  2. 2. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

    Detta är en avhandling från Department of Theoretical Physics, Lund University

    Författare :Liwen You; Högskolan i Halmstad.; Lunds universitet.; Lund University.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Binding affinity; Caspase; Cleavage predition; Cleavage specifictiy; Epitope; False positive; Gaussian process; HCV; Hierarchial method; HIV; Immunology; MHC; OSRE; Protease-peptide interaction; Rule extraction; Sequence analysis; SVM; medical informatics; biomathematics biometrics; sequence analysis; rule extraction; protease-peptide interaction; immunology; hierarchical method; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll;

    Sammanfattning : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. LÄS MER

  3. 3. Cleavage Specificity of Mast Cell Chymases

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mattias K. Andersson; Uppsala universitet.; [2008]
    Nyckelord :Biology; Immunology; Mast cell; Serine protease; Chymase; Cleavage specificity; Phage display; Biologi;

    Sammanfattning : Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in IgE mediated allergies. However, they also provide beneficial functions to the host, e.g. in bacterial and parasitic defence. LÄS MER

  4. 4. Cutting Edge – Cleavage Specificity and Biochemical Characterization of Mast Cell Serine Proteases

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ulrika Karlson; Uppsala universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; mast cell; serine protease; tryptase; chymase; substrate specificity; phage display; Biologi; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; molekylär immunologi; Molecular Immunology;

    Sammanfattning : It is well established that mast cells (MC) are key players in airway pathologies such as allergic asthma, but they are also known to contribute to host defense and tissue remodeling. MC serine proteases are the major protein components of mast cell granules and accordingly, are most likely involved in many aspects of MC function. LÄS MER

  5. 5. Homing Endonucleases and Horizontal Gene Transfer in Bacteria and Bacteriophages

    Detta är en avhandling från Stockholm : Institutionen för molekylärbiologi och funktionsgenomik

    Författare :David Nord; Stockholms universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dsDNA cleavage; ribonucleotide reductase; GIY-YIG motif; NATURAL SCIENCES Chemistry Biochemistry Molecular biology; NATURVETENSKAP Kemi Biokemi Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Homing endonuclease genes (HEGs) are selfish genetic elements that mediate their own super-Mendelian inheritance. This is mediated by the homing endonuclease cleavage of a HEG- allele followed by recombination-repair with a HEG+ allele.The majority of the HEGs are encoded in intervening sequences (IVSs). LÄS MER