Sökning: "cell cycle disturbances"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden cell cycle disturbances.

  1. 1. On the cell cycle of Escherichia coli and cell division in Haloferax mediterranei

    Författare :Björn Gullbrand; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Branch; division; Escherichia coli; Haloferax mediterranei; replication; segregation; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; mikrobiologi; Microbiology;

    Sammanfattning : Escherichia coli has served as a model organism for prokaryotes for several decades and is perhaps the most well characterised organism on earth. The use of fluorescence microscopy during recent years has contributed substantially to our understanding of the essential cell cycle processes chromosome replication, chromosome segregation and cell division. LÄS MER

  3. 2. Experimental radioimmunotherapy and effector mechanisms

    Författare :David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

    Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER

  4. 3. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Författare :Siri Malmgren; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER

  5. 4. Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats

    Författare :Karin Orre; Enheten för psykiatrisk neuromodulering (PNU); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lithium; electroconvulsive seizures; mood disorder; gliogenesis; amnesia; oligodendrogenesis; myelination; NG2 cells;

    Sammanfattning : Depression and bipolar disorder, collectively known as mood disorders, are devastating, common and often chronic illnesses. Imaging studies of patients with mood disorders have demonstrated structural changes in several brain regions implicated in mood regulation. LÄS MER

  7. 5. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Författare :Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Sammanfattning : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. LÄS MER