Sökning: "whole blood loop system"

Hittade 4 avhandlingar innehållade orden whole blood loop system.

  1. 1. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 2. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

    Författare :Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

    Sammanfattning : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. LÄS MER

  4. 3. Platelet Activation and Inhibition in Connection with Vascular Stents

    Författare :Kjeld Christensen; Rolf Larsson; Sten Husted; Uppsala universitet; []
    Nyckelord :Medicine; platelets; inhibition; activation; stents; ACS; Medicin;

    Sammanfattning : This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents. LÄS MER

  5. 4. The Cross-Talk between GABA Signalling and Metabolic Hormones in the Brain and Pancreatic Islets

    Författare :Yang Jin; Bryndis Birnir; Vidar Gundersen; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : GABA is a well-known neurotransmitter that can be synthesized in the central nervous system (CNS) and, interestingly, also in pancreatic islets. Once released, GABA activates GABA-A channels tonically or transiently resulting in different physiological functions. LÄS MER