Sökning: "PD-L1"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet PD-L1.

  1. 1. Epidemiology and prognosis in classical Hodgkin lymphoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter Hollander; Ingrid Glimelius; Rose-Marie Amini; Gunilla Enblad; Lydia Visser; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; rheumatoid arthritis; tumor microenvironment; immunohistochemistry; immune checkpoints; regulatory T lymphocytes; PD-1; PD-L1; Oncology; Onkologi; Patologi; Pathology;

    Sammanfattning : Classical Hodgkin lymphoma (HL) is a B cell derived neoplasm with an overall good prognosis. Its etiology and pathogenesis are largely unknown. The tumor microenvironment consists of sparse malignant cells and abundant leukocytes. LÄS MER

  2. 2. The immune microenvironment of colorectal cancer - Relationship with survival, sidedness, and pre-diagnostic anthropometry

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Jonna Berntsson; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal Cancer; T cells; B cells; PD-1; PD-L1; immune system; prognosis; anthropometry; obesity;

    Sammanfattning : Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. LÄS MER

  3. 3. Mutation and immune profiling of non-small cell lung cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Linnéa La Fleur; Johan Botling; Fernando López-Ríos; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-small cell lung cancer; Tumor microenvironment; Tumor-associated macrophages; Immune infiltrates; PD-L1; Mutation patterns; Immune therapy; MARCO; TP53; STK11; KRAS;

    Sammanfattning : Several novel therapies that target molecular alterations and immune checkpoints in lung cancer have been introduced in the last decade. Still, only a minority of patients obtain long term disease control and overall survival remains poor. LÄS MER

  4. 4. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology Tumour immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  5. 5. Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer: biology and clinical implications

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Författare :Ioannis Zerdes; Karolinska Institutet.; Karolinska Institutet.; [2020]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling axis, immune-related gene signatures and immune cell subpopulations needs to be fully elucidated while the identification of prognostic and predictive biomarkers in BC is of utmost importance. LÄS MER