Sökning: "PD-L1"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet PD-L1.

  1. 1. Epidemiology and prognosis in classical Hodgkin lymphoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter Hollander; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; rheumatoid arthritis; tumor microenvironment; immunohistochemistry; immune checkpoints; regulatory T lymphocytes; PD-1; PD-L1; Oncology; Onkologi; Patologi; Pathology;

    Sammanfattning : Classical Hodgkin lymphoma (HL) is a B cell derived neoplasm with an overall good prognosis. Its etiology and pathogenesis are largely unknown. The tumor microenvironment consists of sparse malignant cells and abundant leukocytes. LÄS MER

  2. 2. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Mangsbo; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology Tumour immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 3. Microarray gene expression in immunological conditions

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Författare :Abdulkareem Musa Heevy Al-Chaqmaqchi; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The use of microarray techniques for gene expression analysis provides a global view of the transcriptional activity in a biological sample. In this thesis two conditions accompanied by disturbance in the immune system are addressed following the changes in gene expression. LÄS MER

  4. 4. Co-stimulatory molecules : Genes to protein in autoimmune and inflammatory disorders

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Priya Sakthivel; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Co ]stimulatory molecules are antigen ]independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied costimulatory pathway is CD28/CTLA ]4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER

  5. 5. Neruons; regulators of CNS inflammation

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Yawei Liu; Lunds universitet.; Lund University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serology; Immunology; T cells; inflammation; neuron; CNS; EAE MS; serologi;

    Sammanfattning : Neurons have been neglected as cells with major immune regulatory function. Here, we present novel data demonstrating that neurons are highly immune competent and play crucial role in regulation of T cell response and CNS inflammation. LÄS MER