Sökning: "Sara Mangsbo"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Sara Mangsbo.

  1. 1. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology Tumour immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  2. 2. Curing Multiple Sclerosis How to do it and how to prove it

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Joachim Burman; Jan Fagius; Angelica Loskog; Sara Mangsbo; Paulo Muraro; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; cerebrospinal fluid; cytokines; hematopoietic stem cell transplantation; immunology; magnetic resonance imaging; multiple sclerosis; neuroimmunology; neurology; Neurology; Neurologi;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for multiple sclerosis (MS) with now more than 600 documented cases in the medical literature. Long-term remission can be achieved with this therapy, but when is it justified to claim that a patient is cured from MS? In attempt to answer this question, the outcome of the Swedish patients is described, mechanisms behind the therapeutic effect are discussed and new tools for demonstration of absence of disease have been developed. LÄS MER

  3. 3. Antibody- and Peptide-based Immunotherapies Proof-of-concept and safety considerations

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erika Fletcher; Sara Mangsbo; Vivianne Malmström; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

    Sammanfattning : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. LÄS MER

  4. 4. Vascular targeting for enhanced cancer immunotherapy

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

  5. 5. CD40L Gene Therapy for Solid Tumors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Sammanfattning : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. LÄS MER