Sökning: "mitotic catastrophe"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden mitotic catastrophe.
1. Optimizing experimental radioimmunotherapy investigating the different mechanisms behind radiation induced cell deathsDetta är en avhandling från Umeå : Umeå Universitet
Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER
- Detta är en avhandling från Umeå : Klinisk mikrobiologi
Sammanfattning : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. LÄS MER
3. Apoptosis, cellular division or mitotic catastrophe? : effects of kinase inhibition and DNa damage in lung cancer cellsDetta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine
Sammanfattning : Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting in the induction of growth arrest and apoptotic cell death. LÄS MER
- Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine
Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER
- Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Oncology-Pathology
Sammanfattning : Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation of the receptor, leading to subsequent activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways. LÄS MER