Sökning: "oxidative stress"

Visar resultat 1 - 5 av 490 avhandlingar innehållade orden oxidative stress.

  1. 1. The oxidative stress response of Francisella tularensis

    Författare :Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. LÄS MER

  2. 2. Exosomes and the NKG2D receptor-ligand system in pregnancy and cancer : using stress for survival

    Författare :Malin Hedlund; Lucia Mincheva-Nilsson; Susanne Gabrielsson; Umeå universitet; []
    Nyckelord :Exsosomes; NKG2D; MICA; MICB; ULBP; human placenta; trophoblast; syncytiotrophoblast; thermal stress; oxidative stress; leukemia; lymphoma; immunologi; Immunology;

    Sammanfattning : Although not obvious at first sight, several parallels can be drawn between pregnancy andcancer. Many proliferative, invasive and immune tolerance mechanisms that supportnormal pregnancy are also exploited by malignancies to establish a nutrient supply andevade or edit the immune response of the host. LÄS MER

  3. 3. Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis : Role of Inflammation and Oxidative Stress

    Författare :Johanna Helmersson; Samar Basu; Bengt Vessby; Tommy Cederholm; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; prostaglandin F2α; F2-isoprostane; interleukin-6; C-reactive protein; serum amyloid A; tocopherols; cardiovascular risk factors; variation; inflammation; oxidative stress; human; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden;

    Sammanfattning : Inflammation and oxidative stress may be involved in atherogenesis. This thesis describes clinical studies of prostaglandin F2α (PGF2α), an inflammatory mediator, and the isoprostane 8-iso-PGF2α, a reliable indicator of oxidative stress, and cytokine-related inflammatory mediators and indicators in healthy subjects and in a population-based cohort of Swedish men. LÄS MER

  4. 4. The conserved methionines in the chloroplast small heat shock protein - Role in chaperone-substrate interactions and effects of methionine sulfoxidation on chaperone activity

    Författare :Niklas Gustavsson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Biochemistry; oxidative stress; thermostability; temperature stress; stress tolerance; sHsp; protein aggregation; molecular chaperone; Heat stress; methionine sulfoxidation; Biokemi; metabolism; Plant biochemistry; Växtbiokemi;

    Sammanfattning : The chloroplast-localized small heat shock protein (sHsp) Hsp21 belongs to the family of alpha-crystallin like sHsps which form large oligomeric structures and protect partly unfolded aggregation-prone proteins against aggregation. The main focus for this thesis has been on the highly conserved methionines in Hsp21. LÄS MER

  5. 5. Effect of Dietary Antioxidants on Oxidative Stress, Inflammation and Metabolic Factors : Studies in Subjects with Overweight and with Type 2 Diabetes

    Författare :Elisabet Rytter; Samar Basu; Bengt Vessby; Anders Sjödin; Helmut Sies; Uppsala universitet; []
    Nyckelord :Antioxidants; supplementation; fruit and vegetables; oxidative stress; isoprostanes; lipid peroxidation; oxidative damage to DNA; glycaemic control; inflammation; overweight; type 2 diabetes; MEDICINE; MEDICIN; Nutrition; Nutrition;

    Sammanfattning : Observational studies have indicated that fruit and vegetables, and dietary antioxidants may play an important role in reducing the risk of chronic diseases, potentially by affecting pathogenic mechanisms such as oxidative stress and inflammation. Clinical trials investigating the effects of supplementation with single or a few antioxidants in high doses have, however, shown inconsistent results and thus have not been able to support the observational findings. LÄS MER