Sökning: "Francisella tularensis"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Francisella tularensis.

  1. 1. Cutaneous resistance against Francisella tularensis

    Författare :Stephan Stenmark; Mikael Rhen; [2004]
    Nyckelord :tularemia; Francisella tularensis; skin; protection; cytokines; T-cells; B-cells; specific antibodies; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other mammals. The ulceroglandular form of the disease is the most common expression in humans with a clinical picture characterized by a skin ulcer, enlarged regional lymph nodes and fever. LÄS MER

  2. 2. The oxidative stress response of Francisella tularensis

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. LÄS MER

  3. 3. The genetic composition and diversity of Francisella tularensis

    Detta är en avhandling från Umeå : Klinisk mikrobiologi

    Författare :Pär Larsson; Anders Sjöstedt; Andrew K. Benson; [2007]
    Nyckelord :Microbiology; tularemia; genotyping; evolution; microarray; genome sequencing; virulence; genome reduction; Mikrobiologi; Francisella tularensis; klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Francisella tularensis is the causative agent of the debilitating, sometimes fatal zoonotic disease tularemia. To date, little information has been available on the genetic makeup of this pathogen, its evolution, and the genetic differences which characterize subspecific lineages. These are the main areas addressed in this thesis. LÄS MER

  4. 4. Francisella tularensis: persistence, dissemination and source attribution a theoretical and computational approach

    Detta är en avhandling från Umeå : Umeå University

    Författare :Chinmay Kumar Dwibedi; Anders Johansson; Pär Larsson; Markus Antwerpen; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; genomics; evolution; microbial forensics; dispersal; persistence; mikrobiologi; Microbiology;

    Sammanfattning : The bacterium Francisella tularensis causing tularemia in humans and other mammals displays little genetic diversity among genomes across temporal and spatial scales. F. tularensis infects humans with an extremely low infectious dose and causes natural seasonal tularemia outbreaks. LÄS MER

  5. 5. Identification of new virulence factors in Francisella tularensis

    Detta är en avhandling från Umeå : Institutionen för Molekylärbiologi, Umeå universitet

    Författare :Anna-Lena Forslund; Åke Forsberg; Elisabeth Carniel; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Francisella tularensis; regulation; virulence; Hfq; DsbA; type IV pili; membrane; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a highly virulent bacterium with an infection dose of less than ten bacteria. The ability of a pathogen to cause infection relies on different virulence mechanisms, but in Francisella tularensis relatively few virulence factors are known. Two F. LÄS MER