Sökning: "Toxikologi"

Visar resultat 26 - 30 av 368 avhandlingar innehållade ordet Toxikologi.

  1. 26. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Författare :Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  3. 27. Regulation of inducible nitric oxide synthase - Consequences in experimental models of bladder disease

    Författare :Rebecka Johansson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Farmakologi; smooth muscle-myosin heavy chain; Pharmacological sciences; pharmacognosy; farmakognosi; farmaci; actin; BDNF; Rho; aminoguanidine; TNF-alpha; IL-1beta; hypertrophy; differentiation; smooth muscle; bladder; nitric oxide; inducible nitric oxide synthase; toxikologi;

    Sammanfattning : Inducible nitric oxide synthase (iNOS) expression is associated with various pathophysiological conditions in the lower urinary tract. The aims of this thesis have been to investigate the regulation of iNOS in bladder smooth muscle cells and the consequences on neuromuscular regulation, cell growth and differentiation. LÄS MER

  4. 28. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) : Brain changes and behavioral impairments following developmental exposure

    Författare :Oskar Karlsson; Eva Brittebo; Nils Gunnar Lindquist; Erika Roman; Sandra Ceccatelli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. LÄS MER

  5. 29. Coxsackievirus B3 Infection and Host Defence Responses Change the Metabolism of PBDE

    Författare :Magnus Lundgren; Nils-Gunnar Ilbäck; Hans Tjälve; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coxsackievirus; environmental pollutants; PBDE; cytokines; chemokines; metabolism; infection; tissue distribution; toxicology; virology; immunology; Toxicology; Toxikologi; Virology; Virologi; Medicine; medicin;

    Sammanfattning : It has been suggested that the rising amounts of chemicals in the environment may affect host resistance and increase susceptibility to infections. Studies have also shown that infections can change the toxicity of pollutants. LÄS MER

  7. 30. Assessment of eosinophil degranulation in allergic diseases and experimental models

    Författare :Monika Malm-Erjefält; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood; histochemistry; cytochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur; animal morphology; Animal anatomy; Djurs anatomi och morfologi; Haematology; cytoplasmic granules ; Hematologi; Respiratory system; extracellulära vätskor; Andningsorganen; toxikologi; farmaci; farmakognosi; Farmakologi; toxicology; pharmacy; pharmacognosy; Klinisk biologi; Pharmacological sciences; Histology; cell separation ; mice; animal models ; biological marker ; transmission electron microscopy allergy; cell degranulation ; Clinical biology; extracellular fluids; eosinophils;

    Sammanfattning : In allergic disorders, the eosinophilic granulocytes migrate to affected tissues and release granule proteins with cytotoxic, immunoregulatory, and remodeling-promoting properties. Given that degranulation is reflected by a loss in eosinophil granule density of living cells, or by cell membrane rupture and release of intact granules, these morphological changes may represent a biomarker of the allergic disease. LÄS MER