Sökning: "toxikologi"
Visar resultat 1 - 5 av 292 avhandlingar innehållade ordet toxikologi.
1. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Detta är en avhandling från Uppsala : Acta Universitatis UpsaliensisSammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER
2. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain Role of Neuromelanin and Cytochrome P450 for Toxicity
Detta är en avhandling från Uppsala : Acta Universitatis UpsaliensisSammanfattning : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. LÄS MER
3. Proteomic Characterization of Induced Developmental Neurotoxicity
Detta är en avhandling från Uppsala : Acta Universitatis UpsaliensisSammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER
4. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes Studies on the Mechanism of Cell Death in the Olfactory Mucosa
Detta är en avhandling från Uppsala : Acta Universitatis UpsaliensisSammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER
5. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology
Detta är en avhandling från Uppsala : Acta Universitatis UpsaliensisSammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER
