Sökning: "toxikologi"

Visar resultat 1 - 5 av 334 avhandlingar innehållade ordet toxikologi.

  1. 1. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Camilla Svensson; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER

  2. 2. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain Role of Neuromelanin and Cytochrome P450 for Toxicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Östergren; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. LÄS MER

  3. 3. Mechanisms behind Cadmium-Induced Teratogenicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Estíbaliz López Fernández de Villaverde; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Cadmium; Teratogenesis; Exencephaly; Mechanisms; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi;

    Sammanfattning : Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium with extremely slow elimination from the body, causes lower birth weight in humans but has not been classify as a human teratogen. Studies in different laboratory animals have shown that cadmium indeed is a potent teratogen. LÄS MER

  4. 4. Proteomic Characterization of Induced Developmental Neurotoxicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Henrik Alm; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER

  5. 5. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Franzén; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi;

    Sammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER