Sökning: "farmakognosi"

Visar resultat 1 - 5 av 77 avhandlingar innehållade ordet farmakognosi.

  1. 1. Bioassay Development for Identification of Cyclooxygenase-2 Inhibitors of Natural Origin

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Therese Ringbom; Angelika Vollmar; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; farmakognosi;

    Sammanfattning : To examine cyclooxygenase-2 (COX-2) inhibitory effects of natural compounds and structurally related compounds, a radiochemical assay for measuring inhibition of COX-2 and COX-1 catalysed prostaglandin biosynthesis was optimised. That process resulted in the development of a reliable assay for finding COX-2 inhibitors in plants, and for investigating plant constituents pertaining to the inhibition of COX-2 and COX-1. LÄS MER

  2. 2. Bioactive Compounds in the Chemical Defence of Marine Sponges Structure-Activity Relationships and Pharmacological Targets

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erik Hedner; Uppsala universitet.; [2007]
    Nyckelord :Pharmacognosy; 5-hydroxytryptamine; agelasine; agelasimine; antibacterial; antifouling; barettin; bromobenzisoxazolone barettin; cytotoxic; marine; secondary metabolite; sponge; Farmakognosi; Agelas; Geodia barretti;

    Sammanfattning : Marine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. LÄS MER

  3. 3. Distribution and Chemical Diversity of Cyclotides from Violaceae Impact of Structure on Cytotoxic Activity and Membrane Interactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Robert Burman; Ulf Göransson; Lars Bohlin; William Gerwick; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. LÄS MER

  4. 4. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jenny Felth; Lars Bohlin; Joachim Gullbo; Ulf Göransson; Thomas Efferth; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. LÄS MER

  5. 5. Studies on the Effects of Plant and Food Constituents on Cyclooxygenase-2 Aspects in Inflammation and Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ulrika Huss; Pia Wuorela; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi;

    Sammanfattning : In inflammatory events, the cyclooxygenase-2 enzyme (COX-2) catalyses prostaglandin biosynthesis. This is a process, which could possibly be affected by natural compounds including those abundant in food. Two systems have been established to enable investigations of the effects of natural compounds on COX-2. LÄS MER