Sökning: "Excitotoxic"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet Excitotoxic.

  1. 1. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) : Brain changes and behavioral impairments following developmental exposure

    Författare :Oskar Karlsson; Eva Brittebo; Nils Gunnar Lindquist; Erika Roman; Sandra Ceccatelli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. LÄS MER

  3. 2. Excitotoxic neurodegeneration in mouse brain : roles of immune cells and cytokines

    Författare :Zhiguo Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Excitotoxic neurodegeneration is a common feature in many neurological diseases. However, the roles of immune cells and cytokines in this process are unclear. To address this issue, we used knockout (KO) mice deficient in various immune cells or cytokines in our studies. LÄS MER

  4. 3. Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration

    Författare :Charlotta Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). LÄS MER

  5. 4. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Författare :Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Nyckelord :Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER

  7. 5. Apoptotic mechanisms in the neonatal brain following hypoxia-ischemia

    Författare :Ylva Carlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia brain caspase-2 cyclophilin D MLK neonatal.;

    Sammanfattning : Neonatal encephalopathy is often perinatally acquired and caused by hypoxia-ischemia (HI). Brain injury develops with a delay, over 12-48 hours, after the insult. Hypothermia, an established neuroprotective treatment, saves 1 infant in 9 from neurological deficits suggesting that there is room for further improvement. LÄS MER