Sökning: "BDNF"

Visar resultat 1 - 5 av 121 avhandlingar innehållade ordet BDNF.

  1. 1. BDNF, impulsiveness and avoidant focused coping in suicide attempters

    Författare :LIVIA AMBRUS; Lund Psykiatri; []
    Nyckelord :BDNF; Aviodant coping; Suicide Attempters; HPA axis; Impulsvieness; BDNF; Avoidant focused coping; HPA axis; attempted suicide; impulsiveness;

    Sammanfattning : Brain-derived neurotrophic factor (BDNF) is an important protein for neuroplasticity and neurogenesis. In this thesis the role of BDNF, in suicidal behaviour was investigated with focus on possible risk factors for suicidal behaviour such as avoidant focused coping, dysfuntional personality traits like impulsiveness and hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis. LÄS MER

  2. 2. Genes to remember : imaging genetics of hippocampus-based memory functions

    Författare :Karolina Kauppi; Lars Nyberg; Jonas Persson; Guillén Fernández; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Imaging genetics; fMRI; Episodic memory; SNP; KIBRA; BDNF; APOE; Hippocampus; Parahippocampus;

    Sammanfattning : In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. LÄS MER

  3. 3. On pathophysiological mechanisms in amyothrophic lateral sclerosis

    Författare :Eva Grundström; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Amyotrophic lateral sclerosis; ALS; spinal cord; motor neuron; cerebrospinal fluid; CSF; muscle; glial cell line-derived neurotrophic factor; GDNF; brain- derived neurotrophic factor; BDNF; ACh; vesamicol; apoptosis; Bax; Bcl-2; neurodegeneration; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disease with unknown ethiology. The aim of this study was to increase understanding of the pathophysiological mechanisms of dying motor neurons and wasting muscle tissue in this particular disorder. LÄS MER

  4. 4. Olfactory Function : The Influence of Demographic, Cognitive, and Genetic Factors

    Författare :Margareta Hedner; Maria Larsson; Lars-Göran Nilsson; Claire Murphy; Stockholms universitet; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Olfaction; odor identification; odor threshold; odor discrimination; aging; gender; ApoE; BDNF; val66met; association study; population-based; psykologi; Psychology;

    Sammanfattning : Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. LÄS MER

  5. 5. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord

    Författare :Lina Pettersson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; trk; spinal cord; sensory neuron; rat; PAC1; PACAP; ORL1; OFQ N; neurotrophin; neuropeptide; nerve transection; nerve compression; inflammatory pain; BDNF; DRG;

    Sammanfattning : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). LÄS MER