Sökning: "Developmental toxicology"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden Developmental toxicology.

  1. 1. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Måns Jergil; Lennart Dencker; Aldert Piersma; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  2. 2. Developmental exposure to mixtures of environmental pollutants Studies on metabolism, developmental processes, and reproductive organs in zebrafish and chicken embryos

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Mentor; Maria Jönsson; Patrick Babin; [2020]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mixtures; Developmental toxicology; Endocrine disrupting chemicals; Metabolism; Feminization; Zebrafish; Chicken embryo; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Sammanfattning : Humans and wildlife are continuously exposed to mixtures of environmental pollutants. Mixture toxicity can be challenging to predict due to interactions between chemicals and thus whole-mixture approaches are crucial in toxicology. LÄS MER

  3. 3. Distribution and Long-term Effects of the Environmental Neurotoxin β-N-methylamino-L-alanine (BMAA) Brain changes and behavioral impairments following developmental exposure

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Oskar Karlsson; Eva Brittebo; Nils Gunnar Lindquist; Erika Roman; Sandra Ceccatelli; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS PDC; Guam; Developmental neurotoxicity; Brain growth spurt; Behavior; Nonprotein amino acid; Excitotoxic; Cyanobacteria; Apoptosis; BMAA; environmental toxin; Algal blooming; Algblomning; algtoxin; alggift; hjärnutveckling; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : Many cyanobacteria are reported to produce the nonprotein amino acid β-N-methylamino-L-alanine (BMAA). Cyanobacteria are extensively distributed in terrestrial and aquatic environments and recently BMAA was detected in temperate aquatic ecosystems, e.g. the Baltic Sea. LÄS MER

  4. 4. Proteomic Characterization of Induced Developmental Neurotoxicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Henrik Alm; Lennart Dencker; R Stuart Cobb; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER

  5. 5. Methylsulphonyl-chlorobenzenes and the olfactory system : Comparative toxicity of the 2,5- and 2,6-dichlorinated isomers in mice

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Fariba Bahrami; [2000]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; NATURAL SCIENCES Biology Organism biology Developmental biology; NATURVETENSKAP Biologi Organismbiologi Utvecklingsbiologi; toxikologi; Toxicology;

    Sammanfattning : Methyl sulphone metabolites of chlorinated aryl hydrocarbons are persistentenvironmental pollutants that can bioaccumulate in animals and humans. Little is known about the toxicological effects of these metabolites and this thesis is an attempt to increase this limited knowledge. LÄS MER