Sökning: "pharmacognosy"

Visar resultat 1 - 5 av 76 avhandlingar innehållade ordet pharmacognosy.

  1. 1. Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Petra Lindholm; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; pharmacognosy; cytotoxicity; antitumour; Nuphar alkaloid; cyclotide; thionin; cardiac glycoside; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi;

    Sammanfattning : The development of resistance by tumour cells to chemotherapeutic agents is a major problem in cancer treatments. One way to counter this is to find compounds with cytotoxic mechanisms other than those of drugs in clinical use today. LÄS MER

  2. 2. Distribution and Chemical Diversity of Cyclotides from Violaceae Impact of Structure on Cytotoxic Activity and Membrane Interactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Robert Burman; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. LÄS MER

  3. 3. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jenny Felth; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. LÄS MER

  4. 4. Studies on the Effects of Plant and Food Constituents on Cyclooxygenase-2 Aspects in Inflammation and Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ulrika Huss; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi;

    Sammanfattning : In inflammatory events, the cyclooxygenase-2 enzyme (COX-2) catalyses prostaglandin biosynthesis. This is a process, which could possibly be affected by natural compounds including those abundant in food. Two systems have been established to enable investigations of the effects of natural compounds on COX-2. LÄS MER

  5. 5. Bioassay Development for Identification of Cyclooxygenase-2 Inhibitors of Natural Origin

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Therese Ringbom; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; PHARMACY Pharmacognosy; FARMACI Farmakognosi; Pharmacognosy; farmakognosi;

    Sammanfattning : To examine cyclooxygenase-2 (COX-2) inhibitory effects of natural compounds and structurally related compounds, a radiochemical assay for measuring inhibition of COX-2 and COX-1 catalysed prostaglandin biosynthesis was optimised. That process resulted in the development of a reliable assay for finding COX-2 inhibitors in plants, and for investigating plant constituents pertaining to the inhibition of COX-2 and COX-1. LÄS MER