Sökning: "Hematologi"

Visar resultat 1 - 5 av 141 avhandlingar innehållade ordet Hematologi.

  1. 1. Clinical and Immunological Studies in Chronic Myeloid Leukaemia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Stina Söderlund; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic myeloid leukaemia; accelerated phase; blast crisis; tyrosine kinase inhibitor; immunology; myeloid-derived suppressor cells; cytokines; proteomics; TKI discontinuation; population-based;

    Sammanfattning : Chronic myeloid leukaemia (CML) is characterised by the constitutively active tyrosine kinase BCR-ABL. Standard treatment with tyrosine kinase inhibitors (TKI) in the chronic phase (CP) of CML conveys excellent long-term prognosis but is associated with side effects and costs. LÄS MER

  2. 2. Towards Gene Therapy of Osteopetrosis

    Detta är en avhandling från Department of Molecular Medicine and Gene Therapy, Lund University

    Författare :Maria Askmyr; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; oc oc mice; osteoclast; hematopoietic stem cells; Hematologi; extracellulära vätskor;

    Sammanfattning : The goal in this thesis is development of gene therapy for malignant infantile osteopetrosis (IMO), a rare but severe genetic bone disease. The concept of osteopetrosis implies dysfunction or lack of osteoclasts, the bone resorbing cells in our body, resulting in failure of normal bone breakdown. LÄS MER

  3. 3. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

    Detta är en avhandling från Gösta Bergh, Kävlingev 1, S-222 40 Lund, Sweden

    Författare :Gösta Bergh; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antisense; leukemia; cell cycle; differentiation; hematopoiesis; p16; p53; tumor suppressor genes; RB; oligonucleotides; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. LÄS MER

  4. 4. Processing of TNF-receptors to soluble receptor forms in myeloid cells

    Detta är en avhandling från Research Department 2, University Hospital, S-221 85 LUND, SWEDEN

    Författare :Flemming Björnberg; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation cytokine TNF receptor; extracellular fluids; Haematology; Hematologi; extracellulära vätskor;

    Sammanfattning : TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. LÄS MER

  5. 5. Hox transcription factors in hematopoiesis

    Detta är en avhandling från Dept. Mol. Med. and Gene Therapy, BMC A12, 221 84, Lund

    Författare :Jon Mar Björnsson; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; extracellulära vätskor; Haematology; hematopoies; tet; Hox; cre lox;

    Sammanfattning : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. LÄS MER