Sökning: "Anders Karlsson"

Visar resultat 41 - 45 av 83 avhandlingar innehållade orden Anders Karlsson.

  1. 41. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

    Författare :Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
    Nyckelord :pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. LÄS MER

  3. 42. Information till föräldrar som har barn med cancer

    Författare :Anders Ringnér; Ulla H Graneheim; Lilian Jansson; Stig Karlsson; Karin Enskär; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; discursive psychology; focus groups; health-care professionals; interventions; parents; paediatric oncology nursing; perceived stress; person-centred information; qualitative content analysis; qualitative interviews; single-case experimental designs; barnonkologisk omvårdnad; diskurspsykologi; fokusgrupper; föräldrar; interventioner; kvalitativ innehållsanalys; kvalitativa intervjuer; personcentrerad information; single-case-studier; stress; vårdare; caring sciences in social sciences; omvårdnadsforskning med samhällsvetenskaplig inriktning;

    Sammanfattning : Bakgrund. Föräldrar till barn som har cancer upplever en livssituation som präglas av osäkerhet och oro och de ställs inför sociala och känslo­mässiga utmaningar. Jämfört med föräldrar till friska barn, upplever de också högre stress och drabbas i större utsträckning av posttraumatiska stres­symptom. LÄS MER

  4. 43. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Författare :Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. LÄS MER

  5. 44. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime

    Författare :Anders Viberg; Marie Sandström; Otto Cars; Mats Karlsson; Hartmut Derendorf; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cefuroxime; pharmacokinetics; pharmacodynamics; dosing individualisation; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. LÄS MER

  7. 45. Ungas samspel i sociala medier : Att balansera mellan ansvar och positionering

    Författare :Liselotte Eek-Karlsson; Lena Fritzén; Linda Reneland-Forsman; Susanne Linnér; Anders Persson; Linnéuniversitetet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; young people; social media; social values; responsibility; social position; discursive patterns; ungdomar; sociala medier; socialt värde; ansvar; social positionering; diskursiva mönster; Education; Pedagogik;

    Sammanfattning : The growing communication that takes place between young people today causes concern. The purpose of this study is to develop in – depth knowledge of the interaction that young people engage in online. LÄS MER