Sökning: "Mats Karlsson"

Visar resultat 1 - 5 av 109 avhandlingar innehållade orden Mats Karlsson.

  1. 1. Conduits in coronary artery bypass grafting surgery : Saphenous vein, radial and internal thoracic arteries

    Författare :Mats Dreifaldt; Domingos Souza; Lars Norgren; Mats G. Karlsson; Michael R. Dashwood; Anders Jeppson; Örebro universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac surgery; Coronary artery bypass; Saphenous vein; Radial artery; Internal thoracic artery; Vasa vasorum; Nitric oxide; Graft patency; Medicine; Medicin;

    Sammanfattning : A novel technique for saphenous vein (SV) graft harvesting, the No-touch technique (NT), has been developed at the Dept. of Cardiovascular surgery, Örebro University hospital. With NT the SV is harvested with a pedicle of surrounding tissue. This avoids graft spasm and eliminates the need for distension. LÄS MER

  2. 2. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Författare :Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

  3. 3. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Författare :Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER

  4. 4. T lymphocytes in allergic rhinitis

    Författare :Mats G. Karlsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The role of the T lymphocyte and T cell associated events in the allergic reaction were investigated in the nasal mucosa and in the peripheral blood. Patients with seasonal allergic rhinitis (birch pollen) and healthy controls were subjected to an allergen provocation study during non-pollen season. LÄS MER

  5. 5. Novel methods for estimation of ligand binding kinetics and drug absorption

    Författare :Mats O. Karlsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER