Sökning: "Lena Friberg"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden Lena Friberg.

  1. 1. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

    Författare :Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER

  3. 2. Likhetens rum - olikhetens praktik : om produktion av integration i fyra svenska kommuner

    Författare :Lena Grip; Gunnel Forsberg; Lotta Braunerhielm; Tora Friberg; Karlstads universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; integration; politics; Lefebvre; immigrant women; production of space; integration; integrationspolitik; invandrade kvinnor; Lefebvre; produktion av rum; Human geography; Kulturgeografi; Kulturgeografi; Human Geography;

    Sammanfattning : What is integration? How is integration achieved and to whom is it directed? And how is integration implemented in respect to immigrant women? This thesis examines ideas concerning integration and the policy and practice of integration on the basis of a set of policies which include Swedish society as “multicultural”, with the focus on immigrant women. Integration as a political project exists at a national level in Sweden but also in most of Sweden’s municipalities. LÄS MER

  4. 3. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

    Författare :Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. LÄS MER

  5. 4. Towards Individualized Drug Dosage : General Methods and Case Studies

    Författare :Martin Fransson; Peter Fritzson; Lena Friberg; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; drug dosage; population pharmacokinetics; biochemical modelling; identifiability; parameter estimation; Bioinformatics; Bioinformatik;

    Sammanfattning : Progress in individualized drug treatment is of increasing importance, promising to avoid much human suffering and reducing medical treatment costs for society. The strategy is to maximize the therapeutic effects and minimize the negative side effects of a drug on individual or group basis. LÄS MER

  7. 5. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

    Författare :Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER