Sökning: "Stephan Schmidt"

Hittade 1 avhandling innehållade orden Stephan Schmidt.

1. 1. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

   Författare :Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
   Nyckelord :pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. LÄS MER