Sökning: "pharmacodynamics"

Visar resultat 1 - 5 av 110 avhandlingar innehållade ordet pharmacodynamics.

  1. 1. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Författare :Marie V Magnusson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Sammanfattning : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). LÄS MER

  3. 2. Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT

    Författare :Emma Eckernäs; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; N; N-dimethyltryptamine; psychedelic; nonlinear mixed effects modeling; pharmacokinetics; pharmacodynamics;

    Sammanfattning : N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the human consciousness using brain imaging techniques. LÄS MER

  4. 3. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Författare :Sofia Friberg Hietala; Göteborgs universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Sammanfattning : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. LÄS MER

  5. 4. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Författare :Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER

  7. 5. Premedication for intubation in newborn infants; pain assessment, pharmacokinetics and pharmacodynamics

    Författare :Elisabeth Norman; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Premedication; pain; premature; newborn; aEEG; randomized controlled trial; thiopental; morphine; remifentanil; rapid sequence induction; ibntubation; pharmacokinetics; pharmacodynamics;

    Sammanfattning : Preterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. LÄS MER