Sökning: "piperacillin"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet piperacillin.

  1. 1. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Författare :Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. LÄS MER

  3. 2. Pharmacodynamic effects of antibiotics : studies on bacterial morphology, initial killing, postantibiotic effect and effecitive regrowth time

    Författare :Håkan Hanberger; Otto Cars; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Pharmacodynamics of antibiotics deals with time course of drug activity and mechanisms of action of drugs on bacteria. In this thesis pharmacodynamic parameters have been studied after brief exposure of gram-positive bacteria to daptomycin, imipenem or vancomycin and after short exposure of gram-negative bacteria to amikacin, ampicillin, aztreonam, cefepime, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, imipenem, mecillinal,11, or piperacillin. LÄS MER

  4. 3. Pharmacokinetics and pharmacodynamics of aminoglycosides

    Författare :Barbro Isacsson; Stig Holm; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The pharmacokinetics of amikacin in humans and the pharmacodynamic effects, i.e. initial killing and postantibiotic effect (P AE), of the aminoglycosides were studied in this thesis. LÄS MER

  5. 4. Extended-spectrum beta-lactamase-producing enterobacteriaceae : epidemiology and dynamics of fecal carriage

    Författare :Emilia Titelman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : ESBL-producing Enterobacteriaceae (EPE) has become a major cause of community acquired urinary tract infection (UTI), and fecal carriage of EPE is emerging worldwide. The aims of this thesis were to study the molecular epidemiology of ESBL-enzymes in Stockholm (I) to evaluate treatment alternatives to the carbapenems for EPE (I-III), and to study the duration of fecal carriage and identify factors associated with prolonged carriage (IV). LÄS MER

  7. 5. Molecular Epidemiology and Mechanisms of Antibiotic Resistance in Clinical Isolates of Pseudomonas aeruginosa from Qatar

    Författare :Mazen Sid Ahmed; Jana Jass; Emad Ibrahim; Ali Sultan; Bo Söderquist; Christian Giske; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotics; C T; CZA; MDR; Pseudomonas aeruginosa; ST235; VEB; VIM;

    Sammanfattning : Inappropriate and excessive use of antibiotics promotes antimicrobial resistance (AMR), particularly in Gram-negative bacteria (GNB). There is a noticeable increase in nosocomial infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, which is associated with significant morbidity, mortality, and an increase in cost management. LÄS MER