Sökning: "Pharmaceutical Science"

Visar resultat 1 - 5 av 142 avhandlingar innehållade orden Pharmaceutical Science.

  1. 1. Pharmaceutical Nanocomposites : Structure–Mobility–Functionality Relationships in the Amorphous State

    Författare :Joel Hellrup; Denny Mahlin; Göran Alderborn; László Fábián; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; amorphous; pharmaceutical composites; solid state; structure; molecular mobility; spray-drying; freeze-drying; moisture sorption; physical stability; compression; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. LÄS MER

  2. 2. Application of Artificial Gel Antibodies for the Detection and Quantification of Proteins in Biological Fluids

    Författare :Nasim Ghasemzadeh; Fred Nyberg; Dom M. Desiderio; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The molecular-imprinting method has previously been used for the synthesis of artificial gel antibodies, highly selective for various proteins. In present study, we have synthesized artificial gel antibodies against haemoglobin, albumin and different forms of growth hormone with the aim to develop a simple and rapid procedure to measure the concentration of these protein biomarkers in samples of clinical interest. LÄS MER

  3. 3. Following the mevalonate pathway to bone heal alley

    Författare :Björn Skoglund; Lars Nordsletten; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; MEDICIN OCH HÄLSOVETENSKAP; LANTBRUKSVETENSKAPER; MEDICAL AND HEALTH SCIENCES; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; Pharmaceutical chemistry; Farmaceutisk kemi; Other veterinary medicine; Övrig veterinärmedicin;

    Sammanfattning : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. LÄS MER

  4. 4. Process-induced disorder of pharmaceutical materials : Mechanisms and quantification of disorder

    Författare :Samaneh Pazesh; Göran Alderborn; Jonas Berggren; Niklas Sandler; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milling; Comminution; Powder flow; Amorphisation; Raman spectroscopy; Atomic force microscopy; Plastic stiffness; Elastic stiffness; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : One of the most important prerequisites in the drug development is to attain a reproducible and robust product in terms of its nature, and its chemical and physical properties. This can be challenging, since the crystalline form of drugs and excipients can be directly transformed into the amorphous one during normal pharmaceutical processing, referred to as process-induced amorphisation or process-induced disorder. LÄS MER

  5. 5. Microgels as Carriers for Antimicrobial Peptides : Surface-bound microgels, and factors affecting peptide interactions

    Författare :Lina Nyström; Martin Malmsten; Per Hansson; L. Andrew Lyon; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Antimicrobial peptides; Biomaterial coating; Drug delivery; Host defence peptides; Microgels; pH-responsive; Surface-bound; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Sammanfattning : With a growing number of multi-resistant bacteria against conventional antibiotics, there is an urgent need to identify new antimicrobial therapeutics. One example that has gained considerable interest is antimicrobial peptides (AMPs). LÄS MER