Sökning: "pharmacometrics"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet pharmacometrics.

  1. 1. Development, Application and Evaluation of Statistical Tools in Pharmacometric Data Analysis

    Detta är en avhandling från Uppsala : Avdelningen för farmakokinetik och läkemedelsterapi

    Författare :Lars Lindbom; Uppsala universitet.; [2006]
    Nyckelord :Pharmaceutical biosciences; pharmacometrics; pharmacokinetics; pharmacodynamics; methodology; statistics; model evaluation; resampling methods; Farmaceutisk biovetenskap;

    Sammanfattning : Pharmacometrics uses models based on pharmacology, physiology and disease for quantitative analysis of interactions between drugs and patients. The availability of software implementing modern statistical methods is important for efficient model building and evaluation throughout pharmacometric data analyses. LÄS MER

  2. 2. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Kristin E Karlsson; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

  3. 3. Model-Based Optimization of Clinical Trial Designs

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Camille Vong; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

  4. 4. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :João A. Abrantes; Uppsala universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bayesian forecasting; coagulation factor VIII; dose adaptation; hemophilia haemophilia A; inter-occasion variability; NONMEM; pharmacodynamics; pharmacokinetics; pharmacometrics; therapeutic drug monitoring; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. LÄS MER

  5. 5. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Oskar Alskär; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER