Sökning: "pharmacokinetics"

Visar resultat 1 - 5 av 269 avhandlingar innehållade ordet pharmacokinetics.

  1. 1. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Detta är en avhandling från Göteborg : Göteborg University

    Författare :Joel Tärning; Göteborgs universitet.; Gothenburg University.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Sammanfattning : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. LÄS MER

  2. 2. Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Emma Boström; Uppsala universitet.; [2007]
    Nyckelord :Pharmacokinetics Pharmacotherapy; pharmacokinetics; pharamcodynamics; blood-brain barrier; oxycodone; microdialysis; NONMEM; brain distribution; transport; Farmakokinetik Farmakoterapi;

    Sammanfattning : The pharmacokinetics and pharmacodynamics of oxycodone and morphine was investigated and related to the transport across the blood-brain barrier (BBB) in rats. The influence of a P-glycoprotein (P-gp) inhibitor on the plasma pharmacokinetics and pharmacodynamics of oxycodone was evaluated. LÄS MER

  3. 3. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics

    Detta är en avhandling från Göteborg : Göteborgs universitet

    Författare :Mohd Yusmaidie Aziz; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioanalysis; Pharmacokinetics; Piperaquine; Malaria;

    Sammanfattning : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. LÄS MER

  4. 4. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Marie V Magnusson; Lunds universitet.; Lund University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Sammanfattning : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). LÄS MER

  5. 5. Chemotherapy in Childhood Acute Lymphoblastic Leukemia In vitro cellular drug resistance and pharmacokinetics

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Britt-Marie Frost; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; cytotoxicity; drug resistance; pharmacokinetics; Acute lymphoblastic leukemia; childhood; in vitro assay; vincristine; doxorubicin; Down`s syndrome; CHS 828.; Obstetrik och kvinnosjukdomar; MEDICINE Surgery Obstetrics and women s diseases; MEDICIN Kirurgi Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

    Sammanfattning : The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. LÄS MER