Sökning: "insulin response"
Visar resultat 11 - 15 av 462 avhandlingar innehållade orden insulin response.
11. Transport and release of insulin granules during biphasic insulin secretion
Sammanfattning : Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin granule transport, as well as to study the influence of the nucleotides cAMP and NADPH to this process. LÄS MER
12. Insulin Signalling and Regulation of Protein Kinase B in Adipocytes
Sammanfattning : Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. LÄS MER
13. Insulinogenic Effects of Milk- and Other Dietary Proteins, Mechanisms and metabolic implications
Sammanfattning : The metabolic syndrome (type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, dyslipidaemia, and hyperinsulinaemia), is increasing in prevalence world-wide. The progression of this syndrome proceeds through a step-wise deterioration of metabolic events where deterioration of insulin sensitivity appears to have a key role in a ?vicious circle? of hyperinsulinaemia/hyperglycaemia and insulin resistance. LÄS MER
14. Polycystic ovary syndrome : A study on factors of potential impact on body fat and carbohydrate metabolism
Sammanfattning : The aim of the present thesis was to investigate some factors underlying the metabolic, anthropometric, and endocrine abnormalities of women with the polycystic ovary syndrome (PCOS).An iv insulin tolerance test (0.15 IU bolus) showed substantially preserved glucose counterregulation in women with PCOS (n=18). LÄS MER
15. Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up
Sammanfattning : Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules. LÄS MER
