Sökning: "diabetes"

Visar resultat 1 - 5 av 1712 avhandlingar innehållade ordet diabetes.

  1. 1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Detta är en avhandling från Units of Epigenetics and Diabetes and Molecular Metabolism, Department of Clinical Sciences, Malmö

    Författare :Siri Malmgren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER

  2. 2. FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes

    Detta är en avhandling från Endocrinology

    Författare :Emma A Nilsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; Type 2 diabetes; Genetics; Obesity;

    Sammanfattning : The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. LÄS MER

  3. 3. The genetic background of gestational diabetes mellitus

    Detta är en avhandling från Dept of Diabetes and Celiac Disease

    Författare :Anastasia Papadopoulou; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gestational diabetes mellitus; HLA; TCF7L2; PTPN22; Post partum diabetes; Type 1 Diabetes; Type 2 Diabetes; Islet Cell Autoantibodies;

    Sammanfattning : The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum. In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. LÄS MER

  4. 4. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Anders H Olsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Sammanfattning : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. LÄS MER

  5. 5. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Alexander Perfilyev; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Methylation; Adipose Tissue; Illumina 450k methylation array; type 2 diabetes;

    Sammanfattning : Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. LÄS MER