Sökning: "insulin response"

Visar resultat 21 - 25 av 462 avhandlingar innehållade orden insulin response.

  1. 21. Early perturbations in lipid metabolism in insulin resistance

    Författare :Else Hellebö Johanson; Göteborgs universitet; []
    Nyckelord :insulin resistance; nateglinide; peak VO2; postprandial; relatives; triglyceride-rich lipoproteins; visceral fat; VLDL;

    Sammanfattning : Subjects with the Metabolic Syndrome with or without type 2 diabetes are at excess risk for developing cardiovascular disease. The mechanisms are still not completely understood. Resistance to insulin-stimulated glucose uptake is associated with several metabolic and hemostatic risk factors for cardiovascular disease. LÄS MER

  3. 22. Adipocyte phosphatases and the antilipolytic action of insulin

    Författare :Svante Resjö; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein phosphorylation; protein purification; adipose tissue; PP2A; protein phosphatase; PDE3B; phosphodiesterase 3B; Insulin signalling; antilipolysis; Klinisk biologi; Clinical biology; PKB; protein kinase B;

    Sammanfattning : Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. LÄS MER

  4. 23. Lipid Signalling Dynamics in Insulin-secreting β-cells

    Författare :Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. LÄS MER

  5. 24. Perioperative nutrition and insulin resistance

    Författare :Monika Svanfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin sensitivity; insulin resistance; hyperinsulinaemic normoglycaemic clamps; wholebody glucose kinetics; whole-body protein kinetics; indirect calorimetry; surgery; carbohydrate loading; hypocaloric nutrition; bed rest and TPN;

    Sammanfattning : Surgical trauma induces a catabolic response with development of insulin resistance as a central and well-characterised feature. In insulin resistance, the stimulating effect of insulin on peripheral glucose uptake and the suppressing effect of insulin on endogenous glucose release are decreased, resulting in hyperglycaemia. LÄS MER

  7. 25. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Författare :Charlotte Granhall; Genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Sammanfattning : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. LÄS MER