Sökning: "Diabetes - öpatofysiologi"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Diabetes - öpatofysiologi.

  1. 1. Pathophysiology and treatment of defective insulin secretion in diabetes

    Författare :Anders Rosengren; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic beta-cells; stem cells; genetics; exocytosis; Adra2a; PACAP; GLP-1; Physiology; Fysiologi; secreting systems; Endocrinology; diabetology; Endokrinologi; insulin secretion; Diabetes mellitus; sekretion; diabetologi;

    Sammanfattning : Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. LÄS MER

  3. 2. Ion channel control of phasic insulin secretion

    Författare :Xingjun Jing; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phasic insulin secretion; Diabetes; pancreatic β-cells; ClC chloride channel; exocytosis; CaV channel;

    Sammanfattning : Glucose-stimulated insulin secretion exhibits a biphasic pattern. The mechanism underling biphasic insulin secretion is not fully understood, but consensus exists that an elevation in [Ca2+]i is required for both first- and second-phase insulin secretion. LÄS MER

  4. 3. Mechanisms of defective insulin secretion in type 2 diabetes

    Författare :Taman Mahdi; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; Insulin secretion; TCF7L2; ADRA2A; KCNQ1; SFRP4; interleukin-1B;

    Sammanfattning : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. LÄS MER

  5. 4. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Författare :Rui Wu; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Sammanfattning : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). LÄS MER

  7. 5. The Best Leading Role for Maintaining Normal β-cell Function Goes to MafA and Voltage-gated Calcium Channel Subunit γ4

    Författare :Cheng Luan; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; insulin secretion; pancreatic islet; MafA; CaVγ4; CaV channels; β-cell function; dedifferentiation; transcription factor; patch clamp; Ca2 signaling; cholinergic nicotinic receptor; ChrnB4; GDF11; aging; islet inflammation; maturation;

    Sammanfattning : .... LÄS MER