Sökning: "internal medicine"

Visar resultat 1 - 5 av 431 avhandlingar innehållade orden internal medicine.

  1. 1. Brain function and glucocorticoids in obesity and type 2 diabetes including effects of lifestyle interventions

    Författare :Andreas Stomby; Tommy Olsson; Mats Ryberg; Carl-Johan Boraxbekk; Alasdair MacLullich; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; glucocorticoid; cortisol; 11beta hydroxysteroid dehydrogenase type 1; episodic memory; functional magnetic resonance imaging; paleolithic diet; exercise; Internal Medicine; invärtesmedicin; medicin; Medicine;

    Sammanfattning : Background Obesity and associated metabolic dysregulation are linked to impaired cognitive function and alterations in brain structure, which increases the risk of age-related dementia. Increased glucocorticoid (GC) exposure may be a potential mediator of these negative effects on the brain. LÄS MER

  3. 2. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia

    Författare :Anna Eriksson; Martin Höglund; Rolf Larsson; Bjørn Tore Gjertsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Targeted therapies; Drug development; Tyrosine kinase inhibition; AKN-032; AKN-028; Internmedicin; Internal Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. LÄS MER

  4. 3. CXCL16 and CD137 in atherosclerosis

    Författare :Dick Wågsäter; Allan Sirsjö; Ewa Ehrenborg; Örebro universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; atherosclerosis; chemokine; cytokine; endothelial cells; inflammation; low-density lipoprotein; macrophages; scavenger receptor; smooth muscle cells; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Atherosclerosis is a progressive inflammatory disease that is characterized by the accumulation of lipids, infiltrated cells and fibrous elements in large arteries. This thesis focuses on the molecular mechanisms behind foam cell formation and inflammation, two central processes in the development of atherosclerosis. LÄS MER

  5. 4. Carotid stenosis

    Författare :Elias Johansson; Per Wester; Conny Arnerlöv; Arne Lindgren; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carotid stenosis; Risk; Recurrence; Stroke; TIA; Near-occlusion; Carotid Endarterectomy; Delay; Panoramic Radiographs; Cardiovascular medicine; Kardiovaskulär medicin; Neurology; Neurologi; Internal Medicine; invärtesmedicin; neurologi; Neurology; odontologi; Odontology;

    Sammanfattning : Carotid stenosis is one of several causes of ischemic stroke and entails a high risk of ischemic stroke recurrence. Removal of a carotid stenosis by carotid endarterectomy results in a risk reduction for ischemic stroke, but the magnitude of risk reduction depends on several factors. LÄS MER

  7. 5. Neural and Cognitive Effects of Hearing Loss on Speech Processing

    Författare :Eline Borch Petersen; Thomas Lunner; Stefan Stenfelt; Jonas Obleser; Edmund Lalor; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Hearing loss; speech processing; electroencephalogram EEG; working memory; cognitive load; hearing aid; Hörselnedsättning; bearbetning av tal; elektroencefalogram EEG; arbetsminne; kognitiv belastning; hörapparat;

    Sammanfattning : Understanding speech in the presence of noise can be difficult, especially when suffering from a hearing loss. This thesis examined behavioural and electrophysiological measures of speech processing with the aim of establishing how they were influenced by hearing loss (internal degradation) and listening condition (external degradation). LÄS MER