Sökning: "proinsulin"

Visar resultat 1 - 5 av 47 avhandlingar innehållade ordet proinsulin.

  1. 1. Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up

    Författare :Björn Zethelius; Björn Fagerberg; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; diabetes; coronary heart disease; insulin; proinsulin; prognosis; mortality; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Geriatrics; geriatrik;

    Sammanfattning : Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules. LÄS MER

  2. 2. The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin

    Författare :Hans-Erik Johansson; Björn Zethelius; Arvo Hänni; Margareta Öhrvall; Lars Lannfelt; Claes-Göran Östenson; Uppsala universitet; []
    Nyckelord :Proinsulin; insulin; glucose; obesity; bariatric surgery; MEDICINE; MEDICIN;

    Sammanfattning : Hyperproinsulinemia is associated with type 2 diabetes (T2DM) and obesity and is a predictor for future coronary heart disease. This thesis examines the effect of bariatric surgery on glucometabolic status including insulin and proinsulin responses after meal. LÄS MER

  3. 3. Risk Factors for Stroke in Adult Men : A Population-based Study

    Författare :Bernice Wiberg; Lars Lind; Johan Sundström; Björn Zethelius; Peter Appelros; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; risk factor; stroke; TIA; lipoproteins; fatty acids; insulin resistance; proinsulin; clamp; cognitive function; epidemiology; Trail Making Test; stroke mortality; dependency; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In the last decades our knowledge concerning cardiovascular risk factors has grown rapidly through results from longitudinal studies. However, despite new treatment, in Western countries coronary heart disease remains the leading cause of death and stroke is still the leading cause of severe disability. LÄS MER

  4. 4. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Författare :Gabriella Brolén; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Sammanfattning : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. LÄS MER

  5. 5. Risk markers for a first myocardial infarction

    Författare :Anna Margrethe Thøgersen; Annika Rosengren; Umeå universitet; []
    Nyckelord :haemostatis; lipoprotein a ; MTHFR; homocysteine; proinsulin; leptin; apolipoprotein A1; DHEAS; myocardial infarction; risk factors;

    Sammanfattning : The development of a first myocardial infarction is associated with a large number of contributing factors. Age, male sex, hypertension, smoking, diabetes, body mass index and hypercholesterolemia are considered as established risk factors. LÄS MER