Sökning: "klinisk farmaci"
Visar resultat 21 - 25 av 54 avhandlingar innehållade orden klinisk farmaci.
21. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study
Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER
22. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men
Sammanfattning : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. LÄS MER
23. Assessment of eosinophil degranulation in allergic diseases and experimental models
Sammanfattning : In allergic disorders, the eosinophilic granulocytes migrate to affected tissues and release granule proteins with cytotoxic, immunoregulatory, and remodeling-promoting properties. Given that degranulation is reflected by a loss in eosinophil granule density of living cells, or by cell membrane rupture and release of intact granules, these morphological changes may represent a biomarker of the allergic disease. LÄS MER
24. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers
Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER
25. Inhaled pharmacological treatment and critical inhaler technique errors in patients with chronic obstructive pulmonary disease
Sammanfattning : Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterised by persistent respiratory symptoms and a high risk of exacerbations. Preventive and maintenance pharmacological treatment is primarily administered through handheld inhalers, which are available in several different device-drug combinations. LÄS MER