Sökning: "5-fluorouracil"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet 5-fluorouracil.

  1. 1. Intraperitoneal 5-Fluorouracil treatment of cancer - clinical and experimental studies

    Författare :Mikael Öman; Peter Naredi; Larsolof Hafström; Johan Permert; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intraperitoneal; 5-fluorouracil; pancreas cancer; vasopressin; Xenon-clearance; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Background:Pancreas cancer is a most aggressive malignancy. More than 80% of patients diagnosed with pancreas cancer, exhibit such advanced disease, that curative surgery is impossible. Systemic chemotherapy prolongs survival to 5-9 months. LÄS MER

  3. 2. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Författare :Magdalena Cwikiel; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER

  4. 3. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

    Författare :Sara Kinhult; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

    Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER

  5. 4. Effects of 5-fluorouracil on oral barrier functions

    Författare :Inger von Bültzingslöwen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Many anticancer drugs, e.g. 5-fluorouracil (5-FU), may cause oral mucositis and ulcerations. These adverse reactions can be severe and debilitating to the patient, and adjustment of the cancer treatment may be necessary. LÄS MER

  7. 5. Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast

    Författare :Marie Gustavsson; Hans Ronne; Anders Blomberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 5-fluorouracil; tRNA modifications; Saccharomyces cerevisiae; carbamoyl phosphate synthase; V-ATPase; Functional genomics; Funktionsgenomik;

    Sammanfattning : This thesis describes the use of functional genomics screens in yeast to study anticancer drug action and intracellular transport. The yeast Saccharomyces cerevisiae provides a particularly useful model system for global drug screens, due to the availability of knockout mutants for all yeast genes. LÄS MER