Sökning: "cardiotoxicity"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet cardiotoxicity.

  1. 1. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Författare :Magdalena Cwikiel; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER

  3. 2. Microfluidic biosensor systems for cardiotoxicity assaying

    Författare :Gunnar Bergström; Carl-Fredrik Mandenius; Nate Robinson; Staffan Nilsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Toxicity screening is an important part of pharmaceutical development and early detection of toxic side effects provide the opportunity for early redesign or termination of unfeasible projects. Today toxicity testing is relying on experiments on animals. LÄS MER

  4. 3. Assessment of Drug-Induced Cardiotoxicity during Rat Embryo Development

    Författare :Mats Nilsson; William S. Webster; Nigel A. Brown; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The potassium ion channel (hERG/IKr) is important for normal heart function and drug-induced blockade of the channel in adult humans can lead to irregular heart rhythms (arrhythmia).  The ion channel is also essential for early cardiac function in the embryo and therapeutic drugs which block this channel have been shown to cause birth defects in animal studies. LÄS MER

  5. 4. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

    Författare :Sara Kinhult; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

    Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER

  7. 5. Mechanistic insights into the biosynthesis of polyketide antibiotics

    Författare :Azmiri Sultana; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly used anticancer drugs. However, these compounds exhibit severe side effects like cardiotoxicity and multi-drug resistance. LÄS MER