Sökning: "Cisplatin"

Visar resultat 1 - 5 av 107 avhandlingar innehållade ordet Cisplatin.

  1. 1. ASNA1 and cisplatin resistance studies in C. elegans and in human tumor cells

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Oskar Hemmingsson; Umeå universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; MEDICINE Surgery; MEDICIN Kirurgi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; kirurgi; Surgery; onkologi; Oncology; cellforskning; cellforskning;

    Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER

  2. 2. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin Activation and Binding to DNA

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Raber; Uppsala universitet.; [2007]
    Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER

  3. 3. Studies of radioactive cisplatin (191Pt) for tumour imaging and therapy

    Detta är en avhandling från Radiaiton Physics, Malmö University Hospital, SE-205 02 Malmö, Sweden

    Författare :Johan Areberg; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; mice; in vitro; gamma camera; tumour imaging; platinum pharmacokinetics; cisplatin; radioactive; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from 191PtCl4. The 191Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. LÄS MER

  4. 4. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men

    Detta är en avhandling från Anders Johnsson MD, Dept of Oncology, University Hospital, S-21 85 Lund, Sweden

    Författare :Anders Johnsson; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; cancerology; oncology; Cytology; immunohistochemistry; nephrotoxicity; pharmacodynamics; pharmacokinetics; Cisplatin; DNA adducts; platinum; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. LÄS MER

  5. 5. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    Detta är en avhandling från Umeå : Kemiska Institutionen, Umeå universitet

    Författare :Yvonne Nygren; Umeå universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER