Sökning: "Uppsala lennartsson"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Uppsala lennartsson.

1. 1. Stem Cell Factor Induced Signal Transduction

   Författare :Johan Lennartsson; Christer Larsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Stem Cell Factor (SCF) can function as a survival factor, a mitogen or a chemoattractant depending on cell type. Binding of SCF to c-Kit induces dimerization and subsequent autophosphorylation of the receptor. This thesis describes the intracellular signal transduction elicited by c-Kit. LÄS MER

3. 2. Malaria urbana : Om Anna Johannesdotter och prostitutionen i Stockholm kring 1900

   Författare :Rebecka Lennartsson; Karin Salomonsson; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Ethnology; Prostitution; Stockholm; sexuality; gender history; modernity; constructivism; genealogy; discourse; city planning; regulation; power; discipline; gaze; movement; urban disorder; resistance; Etnologi; sexualitet; genushistoria; modernitet; konstruktivism; genealogi; diskurs; stadsplanering; makt; disciplin; rörelse; betraktande; urban oordning; motmakt; Ethnology; Etnologi; Etnologi; Ethnology;

   Sammanfattning : This dissertation deals with regulated prostitution in Stockholm around 1900. The regulation forced women who were regarded as loose to submit to medical examinations twice a weak, and to obey a separate set of rules. The prinicipal and outspoken purpose of this regulation was to restrain the spread of contagious venereal diseases. LÄS MER

4. 3. Regulation and Function of MAP Kinases in PDGF Signaling

   Författare :Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. LÄS MER

5. 4. RhoGTPase Signaling in Cell Polarity and Gene Regulation

   Författare :Ann-Sofi Johansson; Pontus Aspenström; Johan Lennartsson; Christer Larsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RhoGTPase; Par6; cell polarity; aPKC; epithelial cell; PDGF; gene regulation; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. LÄS MER

7. 5. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

   Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER