Sökning: "pericyte"

Visar resultat 1 - 5 av 46 avhandlingar innehållade ordet pericyte.

  1. 1. A functional genomics approach to PDGF and pericyte biology

    Författare :Cecilia Bondjers; Göteborgs universitet; []
    Nyckelord :PDGF; hair follicle; skin; testis; epithelial-mesenchymal interaction; microarray; pericyte; transgenic mouse;

    Sammanfattning : The rapid expansion of genome sequence data demands for increased efforts and speed concerning functional analysis of gene products. Two approaches to such analysis, namely transgenic technologies and analysis of gene expression have successfully been used to study functions of gene products in complex organisms, such as mammals. LÄS MER

  3. 2. Pericyte recruitment and functions in vivo. Studies of platelet-derived growth factor-B deficient embryos

    Författare :Mats Hellström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse; gene targeting; platelet-derived growth factor; pericyte; vascular smooth muscle; angiogenesis;

    Sammanfattning : A functional vascular system is essential for tissue growth and maintenance, and the circulatory system is therefore the first operational organ of the vertebrate embryo. In conditions of pathological tissue growth, such as tumors, formation of new blood vessels is also required, and it is anticipated that prevention of blood vessel development in those settings might ameliorate the disease progress. LÄS MER

  4. 3. Pericyte Influence on Drug Delivery Across the Blood-Brain Barrier : Implications for Therapy of Neurodegenerative Diseases

    Författare :Nebojsa Mihajlica; Margareta Hammarlund-Udenaes; Christer Betsholtz; William Elmquist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; pericytes; pericyte-deficiency; pharmacokinetics; small-molecular drugs; drug distribution; transporters; P-glycoprotein; tyrosine kinase inhibitors; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. LÄS MER

  5. 4. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER

  7. 5. Stem cell based therapy of malignant brain tumors

    Författare :Daniel Bexell; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; pericyte; mesenchymal stem cell; neuroblast; subventricular zone; cancer stem cell; rat; glioma; cancer;

    Sammanfattning : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. LÄS MER