Sökning: "PDGFR"

Visar resultat 1 - 5 av 49 avhandlingar innehållade ordet PDGFR.

  1. 1. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER

  3. 2. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

    Författare :Mahmood Faraz; Håkan Hedman; Roger Henriksson; Rolf Bjerkvig; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; Oncology; onkologi;

    Sammanfattning : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. LÄS MER

  4. 3. Regulation and Function of MAP Kinases in PDGF Signaling

    Författare :Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. LÄS MER

  5. 4. Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling

    Författare :Jeroen Frijhoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor (PDGF R). Signaling via this receptor tyrosine kinase stimulates cell proliferation and migration, and it is associated with cancer and cardiovascular diseases. LÄS MER

  7. 5. Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis

    Författare :Peetra Magnusson; Lena Claesson-Welsh; Anne Eichmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR-1; VEGFR-2; PDGFR-β; endothelial cells; embryonic stem cell; angiogenesis; hematopoiesis; Patologi; Pathology; Patologi;

    Sammanfattning : During development of the mammalian embryo, spatial and temporal expression of fibroblast growth factors (FGFs) and their cognate receptors are vital in the regulation of a number of patterning processes. Inappropriate or decreased expression leads to severe malformations and even embryonic death. LÄS MER