Sökning: "quantitative models"
Visar resultat 1 - 5 av 700 avhandlingar innehållade orden quantitative models.
1. Pharmacometric Models to Improve Treatment of Tuberculosis
Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER
2. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications
Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER
3. Simplifying complex models : Application of modeling tools in exposure assessment of organic pollutants
Sammanfattning : Thousands of chemicals are used in society, but the exposure to humans and other organisms has been measured only for a small number of compounds. Modeling tools constitute low-cost and effective alternatives to measurements for the assessment of exposure. LÄS MER
4. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation
Sammanfattning : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. LÄS MER
5. Quantitative Assessment of Intelligent Transport Systems for Road Freight Transport
Sammanfattning : In this thesis, methods for using computer-based models as support tools for assessing Transport Telematic Services (TTSs) are studied. Such assessments provide one way to understand how TTSs can address problems caused by transportation, such as accidents, emissions, and energy consumption. LÄS MER