Sökning: "Örjan Carlborg"
Hittade 5 avhandlingar innehållade orden Örjan Carlborg.
1. Complex Trait Genetics : Beyond Additivity
Sammanfattning : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. LÄS MER
2. Numerical Algorithms for Mapping of Multiple Quantitative Trait Loci in Experimental Populations
Sammanfattning : Most traits of medical or economic importance are quantitative, i.e. they can be measured on a continuous scale. Strong biological evidence indicates that quantitative traits are governed by a complex interplay between the environment and multiple quantitative trait loci, QTL, in the genome. LÄS MER
3. The impact of selection on the genetic architecture of complex traits
Sammanfattning : Accurate dissection of highly polygenic traits is difficult, in part due to the power required to identify and characterise minor loci, but also due to the potential nonadditive interactions between the contributing genetic variations within a population. This is often further complicated by the genetic features of natural or agricultural populations, where a good understanding of the genetic architecture of a quantitative trait, e. LÄS MER
4. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation
Sammanfattning : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. LÄS MER
5. Understanding the genetic basis of complex traits
Sammanfattning : Recent advances in genetics and genomics have provided numerous opportunities to study the genetic basis of complex traits. Nevertheless, dissecting the genetic basis of complex traits is still challenged by the complex genetic architecture, in which many genes are involved, and many have small contributions to phenotypic variation, interactions with other genes or environmental factors. LÄS MER