Sökning: "time-to-event"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet time-to-event.

  1. 1. A percentile approach to time-to-event outcomes

    Författare :Andrea Bellavia; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : Evaluating survival percentiles is a possible approach for the analysis of time-to-event outcomes that moves the focus from risk to time, as the proportion of events is xed and the time by which that proportion is achieved is investigated. The development of statistical methods for conditional censored quantiles has opened up the possibility to use this approach in epidemiological studies. LÄS MER

  2. 2. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

    Författare :Jacob Leander; Chalmers University of Technology; []
    Nyckelord :time-to-event; mathematical modeling; dynamical systems; parameter estimation; pharmacodynamics; mixed effects; drug development; pharmacokinetics; pharmacometrics;

    Sammanfattning : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. LÄS MER

  3. 3. Pharmacometric Models to Improve Treatment of Tuberculosis

    Författare :Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER

  4. 4. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Författare :Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. LÄS MER

  5. 5. Pharmacometric Methods and Novel Models for Discrete Data

    Författare :Elodie L Plan; Mats O Karlsson; Laura Sargentini-Maier; Armel Stockis; Christian Laveille; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacodynamics; disease progression; modelling; discrete data; count; ordered categorical; repeated time-to-event; RTTCE; RCEpT; NONMEM; FOCE; LAPLACE; SAEM; AGQ; pain scores; epilepsy seizures; gastroesophageal symptoms; statistical power; simulations; diagnostics; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. LÄS MER