Sökning: "Metabolic activation"

Visar resultat 1 - 5 av 236 avhandlingar innehållade orden Metabolic activation.

  1. 1. Microbial modulation of metabolic diseases

    Författare :Antonio Molinaro; Göteborgs universitet.; Gothenburg University.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiota; Glucose Metabolism; type 2 diabetes; NAFLD; non-alcoholic fatty liver disease;

    Sammanfattning : The gut microbiota, the ensemble of microorganisms living in the gastrointestinal tract, and the host have a mutualist relationship. Alterations of this delicate equilibrium can lead to changes in microbiota composition and/or function leading to the onset of metabolic diseases (e.g., type 2 diabetes and non-alcoholic fatty liver diseases). LÄS MER

  2. 2. Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites. Synthesis, Characterization and Avoidance

    Detta är en avhandling från Göteborg

    Författare :Tove Johansson Mali´n; Göteborgs universitet.; Gothenburg University.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; Drug; Electrochemical oxidation; Electrochemistry; Intermediate; Metabolism; Metabolic activation; Mimicry; Reactive Metabolite; Trapping.;

    Sammanfattning : During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and intermediates. Reactive metabolites may represent obstacles in the development and use of drugs, due to their potential toxicity. LÄS MER

  3. 3. Clinical studies in severe heart failure : neurohormonal, electrolyte and metabolic aspects

    Detta är en avhandling från Linköping : Linköpings universitet

    Författare :Mats Broqvist; Linköpings universitet.; Linköpings universitet.; [1994]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : Congestive heart failure is a common and complex syndrome with a poor prognosis. Although heart disease is usually the primary event, the clinical syndrome is characterised by several extra-cardiac manifestations. Neurohormonal activation seems to play a crucial role for these manifestations and the progression of the disease. LÄS MER

  4. 4. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Detta är en avhandling från Uppsala, Sweden : Acta Universitatis Upsaliensis

    Författare :Vendela Asp; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; NATURAL SCIENCES Biology Cell and molecular biology Toxicology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

  5. 5. Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Ulrikke Voss; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enteric nervous system; high fat diet; neuropathy; neuroplasticity; metabolic imbalance;

    Sammanfattning : Popular Abstract in Swedish I min barndom hängde denna affisch på dörren till mitt klassrum i grundskolan. Titeln var: Du är vad du äter. På affischen springer olika matvaror i kapp och det är självklart rågbrödet, mjölken och moroten som vinner, medan glass, godis och pommes frites kommer sists. LÄS MER