Sökning: "modified drug release"

Visar resultat 11 - 15 av 29 avhandlingar innehållade orden modified drug release.

  1. 11. Development of Nanoporous Inorganic Carbonates for Pharmaceutical and Environmental Applications

    Författare :Maria Vall; Ocean Cheung; Maria Strømme; Jessica Rosenholm; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Mesoporous magnesium carbonate; drug delivery; water purification; CO2 capture; catalysis; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Sammanfattning : Mesoporous magnesium carbonate (MMC) is a highly porous, anhydrous material which can be synthesized without the use of templates. This thesis shows how post- and in synthesis modification of MMC can create porous inorganic carbonates suitable for different pharmaceutical and environmental applications. LÄS MER

  3. 12. Metabolic roles of adenosine : studies using genetically modified mice and transfected cells

    Författare :Stina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; A1 receptor; adipocyte; pancreas; skeletal muscle; GHSR1a; caffeine; metabolism and knock out mouse;

    Sammanfattning : The aim of this thesis was to further investigate the metabolic roles of adenosine. The endogenous nucleoside adenosine acts by binding to the four adenosine receptors, A1R, A2AR, A2BR and A3R. The A1R is the adenosine receptor that has been proposed to be the one most involved in metabolism. LÄS MER

  4. 13. Ceramic Materials for Administration of Potent Drugs

    Författare :Bing Cai; Susanne Bredenberg; Håkan Engqvist; Wei Xia; Miguel Manzano García; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Tamper-resistance; Oral formulation; Transdermal formulation; Biomaterials; Microneedles;

    Sammanfattning : This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions.Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. LÄS MER

  5. 14. Multiscale X-ray Characterisation of Cellulose-based Solid Dispersions

    Författare :Martina Olsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PXCT; WAXS; pharmaceutical formulations; multiscale characterisation; STXM; radiation damage; SAXS; X-ray imaging; solid dispersions; cellulose;

    Sammanfattning : Cellulose-based solid dispersions are a promising formulation strategy for providing controlled drug release and dissolution enhancement of poorly soluble drugs. These dispersions can from structures on multiple length scales which can have both positive and negative effects on the functional properties of the formulation. LÄS MER

  7. 15. CELL PENETRATING PEPTIDES : CHEMICAL MODIFICATION AND FORMULATION DEVELOPMENT

    Författare :Kariem Ezzat; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Cell penetrating peptides (CPPs) have been extensively studied and exploited as drug delivery vectors for a wide variety of therapeu-tic cargos. However, several issues remain to be addressed regarding the enhancement of their efficiency and stability. LÄS MER