Sökning: "modified drug release"

Visar resultat 16 - 20 av 29 avhandlingar innehållade orden modified drug release.

1. 16. Towards a responsive functional material: Modification of porosity and grafting of poly(N-isopropylacrylamide) in mesoporous silica SBA-15

   Författare :Nina Reichhardt; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mesoporous silica; SBA-15; intrawall pores; PNIPAAM; lower critical solution temperature; water sorption calorimetry; gas sorption;

   Sammanfattning : Mesoporous silica materials, such as SBA-15, have potential as biocompatible carriers for pharmaceutical applications as well as mini-reactors in e.g. catalysis. This potential arises from their well-defined porous structure on the nanometre scale accompanied by a high internal surface area (800 - 1000 m2/g). LÄS MER

3. 17. Development of Functionalized Protein Materials

   Författare :Yusheng Yuan; Niclas Solin; Olle Inganäs; Qi Zhou; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Many proteins are available as side-streams from food production, and in some cases even from industrial waste-streams. This means that proteins are available in large scale and at a relatively low price. As protein are highly complex molecules it is interesting to try to use protein as starting materials in for applications in materials science. LÄS MER

4. 18. Apoptosis, cellular division or mitotic catastrophe? Effects of kinase inhibition and DNa damage in lung cancer cells

   Författare :Anna Therése Helén Hemström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting in the induction of growth arrest and apoptotic cell death. LÄS MER

5. 19. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

   Författare :Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

   Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER

7. 20. Macro-, Micro- and Nanospheres from Cellulose : Their Preparation, Characterization and Utilization

   Författare :Christopher Carrick; Lars Wågberg; Derek Gray; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cellulose; sphere; capsule; functionalization; Fiber- och polymervetenskap; Fibre and Polymer Science;

   Sammanfattning : The structure of a polymeric material has a great influence in many fundamental scientific areas as well as in more applied science, since it affects the diffusion, permeability, mechanical strength, elasticity, and colloidal properties of the materials. The results in this thesis demonstrate that it is possible to fabricate solid and hollow cellulose spheres with a cellulose shell and encapsulated gas, liquid or solid particles and with a sphere size ranging from a few hundreds of nanometres to several millimetres, all with a tailored design and purpose. LÄS MER