Sökning: "Ülo Langel"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Ülo Langel.

  1. 1. Cell-Penetrating Peptides for Mitochondrial Targeting

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. LÄS MER

  2. 2. Chimeric gene delivery vectors Design, synthesis, and mechanisms from transcriptomics analysis

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Moataz Dowaidar; Ülo Langel; Sandrine Sagan; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; magnetic nanoparticles; graphene oxide; autophagy; siRNA; SCO; QSAR; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. LÄS MER

  3. 3. In-silico design of peptide-based transfection systems, in-vitro validation, and up-take pathways investigation

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Moataz Dowaidar; Ülo Langel; IngMarie Nilsson; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; QSAR; PepFect; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Cell-penetrating peptide-based transfection systems (PBTS) are a promising group of drug delivery vectors. Cell-penetrating peptides (CPPs) are short cationic peptides that are able of transporting cell non-permeant cargos into different cell types. LÄS MER

  4. 4. Gene therapy tools: oligonucleotides and peptides

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Jonas Eriksson; Ülo Langel; Jens Kurreck; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. LÄS MER

  5. 5. Complexes of cell-penetrating peptides with oligonucleotides Structure, binding and translocation in lipid membranes

    Detta är en avhandling från Stockholm : Department of Neurochemistry, Stockholm University

    Författare :Luis Daniel Ferreira Vasconcelos; Ülo Langel; William C. Wimley; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; oligonucleotide; transfection; non-covalent complexes; membrane interaction; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The fundamental element of life known to man is the gene. The information contained in genes regulates all cellular functions, in health and disease. The ability to selectively alter genes or their transcript intermediates with designed molecular tools, as synthetic oligonucleotides, represents a paradigm shift in human medicine. LÄS MER