Sökning: "solid dispersions"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden solid dispersions.

  1. 1. Multiscale X-ray Characterisation of Cellulose-based Solid Dispersions

    Författare :Martina Olsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PXCT; WAXS; pharmaceutical formulations; multiscale characterisation; STXM; radiation damage; SAXS; X-ray imaging; solid dispersions; cellulose;

    Sammanfattning : Cellulose-based solid dispersions are a promising formulation strategy for providing controlled drug release and dissolution enhancement of poorly soluble drugs. These dispersions can from structures on multiple length scales which can have both positive and negative effects on the functional properties of the formulation. LÄS MER

  3. 2. PEG and lipids in solid dispersions and liquid crystals - structure and phase behaviour

    Författare :Johan Unga; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bicontinuous sponge phase; polyethylene glycol; monoolein; bicontinuous cubic phase; lipids; differential scanning calorimetry; phytantriol; small angle X-ray diffraction; solid dispersions;

    Sammanfattning : In this thesis, two different kinds of nano-structured systems have been studied; solid dispersion systems of polyethylene glycol (PEG) and liquid crystalline systems containing the polar lipids monoolein (MO) and phytantriol (PT). Solid dispersions of PEG were studied with addition of different substances, lipids or parabens. LÄS MER

  4. 3. Film Formation from Dispersions - Preparation and Mechanisms

    Författare :Stefan Erkselius; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymerteknik; biopolymers; Polymer technology; decomposition; sodium persulfate; hyrdoxyethyl cellulose; salt; surfactants; drying; stabilization; latex; Film formation; dispersions;

    Sammanfattning : Improved environmental consciousness and harsh legislation concerning volatile organic compounds (VOCs) during the 1980s led to an increase in the development in the field of polymer colloids. Solvent born coatings were replaced by polymer dispersions in aqueous solution, so called latex dispersions. LÄS MER

  5. 4. Drugs and polymers in dissolving solid dispersions : NMR imaging and spectroscopy

    Författare :Carina Dahlberg; István Furó; Anna Millqvist-Fureby; Michael Schuleit; Jadwiga Tritt-Goc; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physical chemistry; Fysikalisk kemi; Surface and colloid chemistry; Yt- och kolloidkemi; PHARMACY; FARMACI;

    Sammanfattning : The number of poorly water-soluble drug substances in the pharmaceutical pipeline is increasing, and thereby also the need to design effective drug delivery systems providing high bioavailability. One favourable formulation approach is preparation of solid dispersions, where dispersing a poorly water-soluble drug in a water-soluble polymer matrix improves the dissolution behaviour and the bioavailability of the drug. LÄS MER

  7. 5. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

    Författare :Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
    Nyckelord :Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. LÄS MER