Sökning: "radiation damage"

Visar resultat 1 - 5 av 195 avhandlingar innehållade orden radiation damage.

  1. 1. Modern Computational Physical Chemistry An Introduction to Biomolecular Radiation Damage and Phototoxicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jorge Llano; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; statistical mechanics; biophysical chemistry; interface; surface thermodynamics; bioelectrochemistry; ionizing radiation; radiation therapy; condensed matter; computational chemistry; nucleic acids; radiation damage; electrode potential; electronic transport; photochemistry; strand break; photodynamic action; cytostatic; solvation; solvated electron; absolute potential; chemical potential; Biologi; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi;

    Sammanfattning : The realm of molecular physical chemistry ranges from the structure of matter and the fundamental atomic and molecular interactions to the macroscopic properties and processes arising from the average microscopic behaviour.Herein, the conventional electrodic problem is recast into the simpler molecular problem of finding the electrochemical, real chemical, and chemical potentials of the species involved in redox half-reactions. LÄS MER

  2. 2. Radiation response in human cells DNA damage formation, repair and signaling

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ann-Sofie Gustafsson; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  3. 3. The microdosimetric variance-covariance method used for beam quality characterization in radiation protection and radiation therapy

    Detta är en avhandling från Stockholm : Medicinsk strålningsfysik (tills m KI)

    Författare :Jan Erik Lillhök; Stockholms universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; radiation quality; radiation protection; radiation therapy; microdosimetry; nanodosimetry; variance-covariance method; MEDICINE Physiology and pharmacology Radiological research Radiological physics; MEDICIN Fysiologi och farmakologi Radiologisk forskning Radiofysik; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : Radiation quality is described by the RBE (relative biological effectiveness) that varies with the ionizing ability of the radiation. Microdosimetric quantities describe distributions of energy imparted to small volumes and can be related to RBE. LÄS MER

  4. 4. Formation and repair of complex DNA damage induced by ionizing radiation

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Karin Magnander; Göteborgs universitet.; Gothenburg University.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; clustered damage; chromatin structure; DSB;

    Sammanfattning : DNA is the critical target when cells are exposed to ionizing radiation, a potent stressor with capacity to produce complex DNA damages, thereby increasing the risk of cancer. DNA and associated histones form chromatin, which is an effective protection against ionizing radiation. LÄS MER

  5. 5. Modeling DNA Damage

    Detta är en avhandling från Stockholm : Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi

    Författare :Patric Schyman; Stockholms universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA; Ionizing radiation; DNA radicals; Strand break; Hydrogen abstraction; Density Functional Theory; Car-Parrinello Molecular Dynamics; QM MM; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE).The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). LÄS MER