Sökning: "Joachim Burman"

Hittade 5 avhandlingar innehållade orden Joachim Burman.

1. 1. Curing Multiple Sclerosis : How to do it and how to prove it

   Författare :Joachim Burman; Jan Fagius; Angelica Loskog; Sara Mangsbo; Paulo Muraro; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; cerebrospinal fluid; cytokines; hematopoietic stem cell transplantation; immunology; magnetic resonance imaging; multiple sclerosis; neuroimmunology; neurology; Neurology; Neurologi;

   Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for multiple sclerosis (MS) with now more than 600 documented cases in the medical literature. Long-term remission can be achieved with this therapy, but when is it justified to claim that a patient is cured from MS? In attempt to answer this question, the outcome of the Swedish patients is described, mechanisms behind the therapeutic effect are discussed and new tools for demonstration of absence of disease have been developed. LÄS MER

3. 2. Studies of the Biology of Intrathecal Treatment in Progressive MS

   Författare :Joakim Bergman; Anders Svenningsson; A. Tommy Bergenheim; Jonathan D. Gilthorpe; Joachim Burman; Magnus Andersson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progressive Multiple Sclerosis; intrathecal treatment; Ommaya reservoir; anti-CD20 therapy; microdialysis; cerebrospinal fluid; CNS compartments; Progressiv Multipel Skleros; intratekal behandling; Ommaya reservoar; anti-CD20 terapi; mikrodialys; ryggmärgsvätska; sektioner i centrala nervsystemet; Neurology; neurologi;

   Sammanfattning : Background: Multiple Sclerosis (MS) is a chronic, inflammatory, autoimmune disease, affecting the central nervous system (CNS). About 85% of afflicted present with a relapsing-remitting form of the disease (RRMS), for which a breakthrough in treatment was made in 2008 with rituximab, an antibody directed towards CD20, a surface antigen on B-cells. LÄS MER

4. 3. Towards an Earlier Detection of Progressive Multiple Sclerosis using Metabolomics and Machine Learning

   Författare :Stephanie Herman; Kim Kultima; Ola Spjuth; Joachim Burman; Johan Lengqvist; Camilla Svensson; Gabi Kastenmüller; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bioinformatics; biomarkers; progressive multiple sclerosis; metabolomics; machine learning; advanced analytics; mass spectrometry;

   Sammanfattning : Decision-making guided by advanced analytics is becoming increasingly common in many fields. Implementing computationally driven healthcare solutions does, however, pose ethical dilemmas as it involves human health. LÄS MER

5. 4. In search of lost disease : Clinical, qualitative and imaging studies to investigate long-term effects of autologous haematopoietic stem cell transplantation for multiple sclerosis

   Författare :Andreas Tolf; Joachim Burman; Anne-Marie Landtblom; Tobias Granberg; Laura Airas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; Neurologi;

   Sammanfattning : With the introduction of autologous haematopoietic stem cell transplantation (AHSCT) for the treatment of multiple sclerosis (MS), there are now individuals living without experiencing disease activity of MS. Are they cured? There is a need for terminology to describe the state of these individuals. LÄS MER

7. 5. Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden

   Författare :Christina Zjukovskaja; Joachim Burman; Kim Kultima; Susanna Brauner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AHSCT; HSCT; hematopoietic stem cell transplantation; multiple sclerosis; RRMS; inflammation; biomarkers; АТГСК; ТГСК; Трансплантация гемопоэтических стволовых клеток; рассеянный склероз; воспаление; биомаркеры; AHSCT; HSCT; Hematopoetisk stamcellstransplantation; multipel skleros; RRMS; inflammation; biomarkör; Medicinsk vetenskap; Medical Science;

   Sammanfattning : This thesis investigated the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT) as a treatment of multiple sclerosis. This thesis demonstrates that when compared to one of the most powerful disease-modifying drugs (DMDs), specifically alemtuzumab (ALZ), AHSCT is able to hold its ground. LÄS MER